Initially I wasn’t too sure how you would translate grids to web pages, but this blog post and presentation, certainly helped in letting the penny drop. The presentation goes into a lot of depth about grid based design and takes you through calculating your grid to applying a design.

There’s also a healthy discussion going on around the web about the pros and cons of the framework which has the Standardista’s up in arms, but gets a lot of backing from folks who just want to get the job done.

My initial impression is very favourable. For those who want to read more here’s a bunch of additional links:

• Blueprint Grid CSS Generator
• Blueprint: A CSS Framework (Updated to 0.5)
• Raging Thunderbolt
• BlueprintCSS 101
• First Impressions of the Blueprint CSS Framework